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American Cruise Lines offers a variety of cruise itineraries throughout the United States, including river cruises on the Mississippi River, Southeast US, Northeast US, Alaska, and the Pacific Northwest.

Mississippi River Cruises

New England Cruises

Pacific Northwest & Alaska Cruises

Southeast Cruises

Themed Cruises

Music Cruise

Music Cruise

Delight in the sounds of Jazz and Blues that fill the air as we cruise the Mississippi River and...

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The American Cruise Lines Difference

Delicious Cuisine
Gracious Service
Nightly Entertainment
First Class Staterooms